Macrophage inhibitory factor 1 acts as a potential biomarker in patients with esophageal squamous cell carcinoma and is a target for antibody‐based therapy

Macrophage inhibitory factor 1 (MIC1) is frequently altered in various cancers. The aim of this study was to investigate the clinical significance of MIC1 for esophageal squamous cell carcinoma (ESCC). Serum MIC1 of 286 ESCC and 250 healthy subjects was detected, the diagnostic performance was asses...

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Veröffentlicht in:	Cancer science 2014-02, Vol.105 (2), p.176-185
Hauptverfasser:	Wang, Xiao‐Bing, Jiang, Xing‐Ran, Yu, Xi‐Ying, Wang, Lin, He, Shun, Feng, Fei‐Yue, Guo, Li‐Ping, Jiang, Wei, Lu, Shih‐Hsin
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibodies - administration & dosage Apoptosis Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - immunology Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Cell growth Cell Line Cell Line, Tumor Cytokines Diagnosis Disease Progression Esophageal cancer Esophageal Neoplasms - blood Esophageal Neoplasms - drug therapy Esophageal Neoplasms - immunology Esophageal Neoplasms - metabolism Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophageal Squamous Cell Carcinoma Esophagus Female Growth Differentiation Factor 15 - blood Growth Differentiation Factor 15 - immunology Growth Differentiation Factor 15 - metabolism Human Umbilical Vein Endothelial Cells Humans Lymph nodes Lymphatic Metastasis macrophage inhibitory factor 1 Macrophages Male Medical prognosis Metastases Metastasis Mice Mice, Inbred BALB C Mice, Nude Middle Aged Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Neovascularization, Pathologic - blood Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Original Prognosis R&D Random Allocation Research & development Squamous cell carcinoma Studies Surgery target Therapeutic applications Transcription Transcription, Genetic - drug effects Tumorigenesis Tumors Up-Regulation - drug effects Vascularization Xenograft Model Antitumor Assays Xenografts
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Zusammenfassung:	Macrophage inhibitory factor 1 (MIC1) is frequently altered in various cancers. The aim of this study was to investigate the clinical significance of MIC1 for esophageal squamous cell carcinoma (ESCC). Serum MIC1 of 286 ESCC and 250 healthy subjects was detected, the diagnostic performance was assessed and compared with SCC, CEA, CA199 and CA724, and the value as a prognostic indicator was also evaluated. The expression of MIC1 in ESCC cell lines, tissues were detected, and the inhibition of MIC1 antibody on ESCC was carried out in vitro and in vivo. The results showed that the serum MIC1 of ESCC was significantly higher than normal groups (P
ISSN:	1347-9032 1349-7006
DOI:	10.1111/cas.12331