Response to Comment “Transient Complexes between Dark Rhodopsin and Transducin: Circumstantial Evidence or Physiological Necessity?” by D. Dell’Orco and K.-W. Koch

In retinal rod cells, absorption of a photon by the visual GPCR rhodopsin (R) initiates a cascade of biochemical reactions that amplifies the light signal and eventually generates an electrical response. Despite a vast number of experimental and simulation studies, the precise spatiotemporal mechanism by which rod cell phototransduction occurs on the supramolecular level is still elusive. As yet, the simultaneous observation of structure and dynamics in intact rod cells goes beyond experimental capabilities.