Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling

Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling

Solid phase synthesis of HBS helices involving the Fukuyama-Mitsunobu reaction and triphosgene coupling is described.

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Veröffentlicht in:Organic & biomolecular chemistry 2010-04, Vol.8 (8), p.1773-1776
Hauptverfasser: Patgiri, Anupam, Witten, Michael R, Arora, Paramjit S
Format: Artikel
Sprache:eng
Schlagworte:
Amides - chemical synthesis
Amides - chemistry
Hydrogen Bonding
Protein Structure, Secondary
Proteins - chemical synthesis
Proteins - chemistry
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Zusammenfassung:Solid phase synthesis of HBS helices involving the Fukuyama-Mitsunobu reaction and triphosgene coupling is described.
ISSN:1477-0520
1477-0539
DOI:10.1039/c000905a