Biocompatibility and osteogenic properties of porous tantalum
Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscop...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2015-03, Vol.9 (3), p.780-786 |
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| creator | WANG, QIAN ZHANG, HUI LI, QIJIA YE, LEI GAN, HONGQUAN LIU, YINGJIE WANG, HUI WANG, ZHIQIANG |
| description | Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum-host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum-host bone interface and pores. By week 12, the tantalum-host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non-toxic, biocompatible and a promising material for use in bone tissue engineering applications. |
| doi_str_mv | 10.3892/etm.2015.2208 |
| format | Article |
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In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum-host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum-host bone interface and pores. By week 12, the tantalum-host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non-toxic, biocompatible and a promising material for use in bone tissue engineering applications.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2015.2208</identifier><identifier>PMID: 25667628</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Analysis ; biocompatibility ; Biomechanics ; Biomedical materials ; bone tissue engineering ; Bones ; cell toxicity ; Chemical properties ; Cytotoxicity ; Friction ; Genetic aspects ; Health aspects ; Joint surgery ; Osteoblasts ; osteogenesis ; Physiological aspects ; Porous materials ; porous tantalum ; Rabbits ; Skin & tissue grafts ; Tissue engineering ; Transplants & implants</subject><ispartof>Experimental and therapeutic medicine, 2015-03, Vol.9 (3), p.780-786</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><rights>Copyright © 2015, Spandidos Publications 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-efea871b21828204e131d416302ef1aa3426e4dd720afc174a8bfbf550076ac23</citedby><cites>FETCH-LOGICAL-c514t-efea871b21828204e131d416302ef1aa3426e4dd720afc174a8bfbf550076ac23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316955/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316955/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,883,27911,27912,53778,53780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25667628$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, QIAN</creatorcontrib><creatorcontrib>ZHANG, HUI</creatorcontrib><creatorcontrib>LI, QIJIA</creatorcontrib><creatorcontrib>YE, LEI</creatorcontrib><creatorcontrib>GAN, HONGQUAN</creatorcontrib><creatorcontrib>LIU, YINGJIE</creatorcontrib><creatorcontrib>WANG, HUI</creatorcontrib><creatorcontrib>WANG, ZHIQIANG</creatorcontrib><title>Biocompatibility and osteogenic properties of porous tantalum</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>Porous tantalum has been reported to be a promising material for use in bone tissue engineering. In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum-host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum-host bone interface and pores. By week 12, the tantalum-host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non-toxic, biocompatible and a promising material for use in bone tissue engineering applications.</description><subject>Analysis</subject><subject>biocompatibility</subject><subject>Biomechanics</subject><subject>Biomedical materials</subject><subject>bone tissue engineering</subject><subject>Bones</subject><subject>cell toxicity</subject><subject>Chemical properties</subject><subject>Cytotoxicity</subject><subject>Friction</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Joint surgery</subject><subject>Osteoblasts</subject><subject>osteogenesis</subject><subject>Physiological aspects</subject><subject>Porous materials</subject><subject>porous tantalum</subject><subject>Rabbits</subject><subject>Skin & tissue grafts</subject><subject>Tissue engineering</subject><subject>Transplants & implants</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkU1r3DAQhk1oSUKaY6_F0ENP3s7oy_KhhTQ0aSDQS3sWsixtFWzLleRA_n217HbbQKSDxOiZlxFPVb1F2FDZkY82TxsCyDeEgDypzrHtSIOl8Opwh07iWXWZ0gOUxQVKyU-rM8KFaAWR59WnLz6YMC06-96PPj_Veh7qkLINWzt7Uy8xLDZmb1MdXL2EGNZUZz1nPa7Tm-q102Oyl4fzovp58_XH9bfm_vvt3fXVfWM4stxYZ7VssScoiSTALFIcGAoKxDrUmjIiLBuGloB2BlumZe96xzlAK7Qh9KL6vM9d1n6yg7FzjnpUS_STjk8qaK-ev8z-l9qGR8Uoio7zEvD-EBDD79WmrB7CGucys8KOIhAQgP-orR6t8rMLJcxMPhl1xUBy6FgLhdq8QJU92MmbMFvnS_1ZQ7NvMDGkFK07Do6gdh5V8ah2HtXOY-Hf_f_bI_3XWgE-7IG0FFt-COnIlKQivQHaQCuB_gEdr6UK</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>WANG, QIAN</creator><creator>ZHANG, HUI</creator><creator>LI, QIJIA</creator><creator>YE, LEI</creator><creator>GAN, HONGQUAN</creator><creator>LIU, YINGJIE</creator><creator>WANG, HUI</creator><creator>WANG, ZHIQIANG</creator><general>D.A. 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In the present study, the biocompatibility and osteogenic properties of porous tantalum were studied in vitro and in vivo. The morphology of porous tantalum was observed using scanning electron microscopy (SEM). Osteoblasts were cultured with porous tantalum, and cell morphology, adhesion and proliferation were investigated using optical microscopy and SEM. In addition, porous tantalum rods were implanted in rabbits, and osteogenesis was observed using laser scanning confocal microscopy and hard tissue slice examination. The osteoblasts were observed to proliferate over time and adhere to the tantalum surface and pore walls, exhibiting a variety of shapes and intercellular connections. The porous tantalum rod connected tightly with the host bone. At weeks 2 and 4 following implantation, new bone and small blood vessels were observed at the tantalum-host bone interface and pores. At week 10 after the porous tantalum implantation, new bone tissue was observed at the tantalum-host bone interface and pores. By week 12, the tantalum-host bone interface and pores were covered with new bone tissue and the bone trabeculae had matured and connected directly with the materials. Therefore, the results of the present study indicate that porous tantalum is non-toxic, biocompatible and a promising material for use in bone tissue engineering applications.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25667628</pmid><doi>10.3892/etm.2015.2208</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Experimental and therapeutic medicine, 2015-03, Vol.9 (3), p.780-786 |
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| subjects | Analysis biocompatibility Biomechanics Biomedical materials bone tissue engineering Bones cell toxicity Chemical properties Cytotoxicity Friction Genetic aspects Health aspects Joint surgery Osteoblasts osteogenesis Physiological aspects Porous materials porous tantalum Rabbits Skin & tissue grafts Tissue engineering Transplants & implants |
| title | Biocompatibility and osteogenic properties of porous tantalum |
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