Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China
To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in China. The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and rest...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-06, Vol.11 (24), p.3651-3654 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Lu, Xiao-Mei Zhang, Yue-Ming Lin, Ren-Yong Arzi, Gul Wang, Xing Zhang, Ya-Lou Zhang, Yan Wang, Yan Wen, Hao |
| description | To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in China.
The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh's patients with esophageal cancer (EC) and 104 non-cancer controls.
The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) than in control subjects (24.0%) (P |
| doi_str_mv | 10.3748/wjg.v11.i24.3651 |
| format | Article |
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The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh's patients with esophageal cancer (EC) and 104 non-cancer controls.
The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) than in control subjects (24.0%) (P<0.05; OR, 11.13; 95%CI, 5.84-21.22). The difference of GSTM1 null was significantly more frequent in the cancer (34.6%) vs the control group (3.8%) (P<0.05; OR, 13.24; 95%CI, 4.50-38.89). On the other hand, the combination of GSTM1 presence and CYP2E1 c1/c1 genotypes increased the risk for cancer (P<0.05; OR, 13.42; 95%CI, 6.29-28.3).
The CYP2E1 c1/c1, GSTM1 deletion genotypes are genetically susceptible biomarkers for ESCC in Kazakh population. Individuals with allele c1 of RsaI polymorphic locus for CYP2E1 may increase the risk of ESCC. Moreover, CYP2E1 wild type (c1/c1) increased the susceptibility to ESCC risk in Kazakh individuals with GSTM1 presence genotype.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i24.3651</identifier><identifier>PMID: 15968714</identifier><language>eng</language><publisher>United States: Medical Research Center, 1st Teaching Hospital, Xinjiang Medical University, Urumqi 830054,Xinjiang Uygur Autonomous Region, China%Public Health College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China</publisher><subject>Aged ; China - epidemiology ; Cytochrome P-450 CYP2E1 - genetics ; Esophageal Cancer ; Esophageal Neoplasms - ethnology ; Esophageal Neoplasms - genetics ; Female ; Genetic Predisposition to Disease - epidemiology ; Genotype ; Glutathione Transferase - genetics ; Humans ; Kazakhstan - ethnology ; Male ; Middle Aged ; Neoplasms, Squamous Cell - ethnology ; Neoplasms, Squamous Cell - genetics ; Polymorphism, Genetic ; Risk Factors</subject><ispartof>World journal of gastroenterology : WJG, 2005-06, Vol.11 (24), p.3651-3654</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2005 Baishideng Publishing Group Inc. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-2528e6528d7fe43482b9ddc235711a98fedd88285203ac4376a229e9771d7cd93</citedby><cites>FETCH-LOGICAL-c423t-2528e6528d7fe43482b9ddc235711a98fedd88285203ac4376a229e9771d7cd93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/wjg/wjg.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316010/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316010/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15968714$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Xiao-Mei</creatorcontrib><creatorcontrib>Zhang, Yue-Ming</creatorcontrib><creatorcontrib>Lin, Ren-Yong</creatorcontrib><creatorcontrib>Arzi, Gul</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Zhang, Ya-Lou</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Wen, Hao</creatorcontrib><title>Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in China.
The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh's patients with esophageal cancer (EC) and 104 non-cancer controls.
The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) than in control subjects (24.0%) (P<0.05; OR, 11.13; 95%CI, 5.84-21.22). The difference of GSTM1 null was significantly more frequent in the cancer (34.6%) vs the control group (3.8%) (P<0.05; OR, 13.24; 95%CI, 4.50-38.89). On the other hand, the combination of GSTM1 presence and CYP2E1 c1/c1 genotypes increased the risk for cancer (P<0.05; OR, 13.42; 95%CI, 6.29-28.3).
The CYP2E1 c1/c1, GSTM1 deletion genotypes are genetically susceptible biomarkers for ESCC in Kazakh population. Individuals with allele c1 of RsaI polymorphic locus for CYP2E1 may increase the risk of ESCC. Moreover, CYP2E1 wild type (c1/c1) increased the susceptibility to ESCC risk in Kazakh individuals with GSTM1 presence genotype.</description><subject>Aged</subject><subject>China - epidemiology</subject><subject>Cytochrome P-450 CYP2E1 - genetics</subject><subject>Esophageal Cancer</subject><subject>Esophageal Neoplasms - ethnology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Kazakhstan - ethnology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Squamous Cell - ethnology</subject><subject>Neoplasms, Squamous Cell - genetics</subject><subject>Polymorphism, Genetic</subject><subject>Risk Factors</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU2P0zAQhiMEYsvCnRPyAcFlU_yVOLkgoWpZEItAsEhwsqbOJHFJ7GycbNX-Cn4yrlrxcfEc_M4778yTJE8ZXQoli1fbTbO8Y2xpuVyKPGP3kgXnrEx5Ien9ZMEoVWkpuDpLHoWwoZQLkfGHyRnLyrxQTC6SX1-wg8l6F1o7kDVOW0RHGnQ4WUMG3-16Pw6tDX0gviY9TrD2nd1b1xB0-12Pgax-fOaX7IJcfb35yAi4inyAPfxsXwaCwQ8tNAgdCbcz9H4OxGDXEQPO4EisI9-t21hwzQVZtdbB4-RBDV3AJ6d6nnx7e3mzepdef7p6v3pznRrJxZTyjBeYx6dSNUohC74uq8pwkSnGoCxqrKqi4EXGqQAjhcqB8xJLpVilTFWK8-T10XeY1z1WBt00QqeH0fYw7rQHq___cbbVjb_TUrCcMhoNnh8NtuDqmF9v_Dy6GFlHKpzSjEtKWZS9OM0Z_e2MYdK9DYcTgMN4DZ2rMpMsPwjpUWhGH8KI9Z8sjOoD7YOvjrR1pK0PtGPLs393-Ntwwit-A2AwqLc</recordid><startdate>20050628</startdate><enddate>20050628</enddate><creator>Lu, Xiao-Mei</creator><creator>Zhang, Yue-Ming</creator><creator>Lin, Ren-Yong</creator><creator>Arzi, Gul</creator><creator>Wang, Xing</creator><creator>Zhang, Ya-Lou</creator><creator>Zhang, Yan</creator><creator>Wang, Yan</creator><creator>Wen, Hao</creator><general>Medical Research Center, 1st Teaching Hospital, Xinjiang Medical University, Urumqi 830054,Xinjiang Uygur Autonomous Region, China%Public Health College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China</general><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050628</creationdate><title>Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China</title><author>Lu, Xiao-Mei ; Zhang, Yue-Ming ; Lin, Ren-Yong ; Arzi, Gul ; Wang, Xing ; Zhang, Ya-Lou ; Zhang, Yan ; Wang, Yan ; Wen, Hao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-2528e6528d7fe43482b9ddc235711a98fedd88285203ac4376a229e9771d7cd93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aged</topic><topic>China - epidemiology</topic><topic>Cytochrome P-450 CYP2E1 - genetics</topic><topic>Esophageal Cancer</topic><topic>Esophageal Neoplasms - ethnology</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Kazakhstan - ethnology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Squamous Cell - ethnology</topic><topic>Neoplasms, Squamous Cell - genetics</topic><topic>Polymorphism, Genetic</topic><topic>Risk Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Lu, Xiao-Mei</creatorcontrib><creatorcontrib>Zhang, Yue-Ming</creatorcontrib><creatorcontrib>Lin, Ren-Yong</creatorcontrib><creatorcontrib>Arzi, Gul</creatorcontrib><creatorcontrib>Wang, Xing</creatorcontrib><creatorcontrib>Zhang, Ya-Lou</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Wang, Yan</creatorcontrib><creatorcontrib>Wen, Hao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Xiao-Mei</au><au>Zhang, Yue-Ming</au><au>Lin, Ren-Yong</au><au>Arzi, Gul</au><au>Wang, Xing</au><au>Zhang, Ya-Lou</au><au>Zhang, Yan</au><au>Wang, Yan</au><au>Wen, Hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2005-06-28</date><risdate>2005</risdate><volume>11</volume><issue>24</issue><spage>3651</spage><epage>3654</epage><pages>3651-3654</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in China.
The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh's patients with esophageal cancer (EC) and 104 non-cancer controls.
The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) than in control subjects (24.0%) (P<0.05; OR, 11.13; 95%CI, 5.84-21.22). The difference of GSTM1 null was significantly more frequent in the cancer (34.6%) vs the control group (3.8%) (P<0.05; OR, 13.24; 95%CI, 4.50-38.89). On the other hand, the combination of GSTM1 presence and CYP2E1 c1/c1 genotypes increased the risk for cancer (P<0.05; OR, 13.42; 95%CI, 6.29-28.3).
The CYP2E1 c1/c1, GSTM1 deletion genotypes are genetically susceptible biomarkers for ESCC in Kazakh population. Individuals with allele c1 of RsaI polymorphic locus for CYP2E1 may increase the risk of ESCC. Moreover, CYP2E1 wild type (c1/c1) increased the susceptibility to ESCC risk in Kazakh individuals with GSTM1 presence genotype.</abstract><cop>United States</cop><pub>Medical Research Center, 1st Teaching Hospital, Xinjiang Medical University, Urumqi 830054,Xinjiang Uygur Autonomous Region, China%Public Health College, Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China</pub><pmid>15968714</pmid><doi>10.3748/wjg.v11.i24.3651</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2005-06, Vol.11 (24), p.3651-3654 |
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| subjects | Aged China - epidemiology Cytochrome P-450 CYP2E1 - genetics Esophageal Cancer Esophageal Neoplasms - ethnology Esophageal Neoplasms - genetics Female Genetic Predisposition to Disease - epidemiology Genotype Glutathione Transferase - genetics Humans Kazakhstan - ethnology Male Middle Aged Neoplasms, Squamous Cell - ethnology Neoplasms, Squamous Cell - genetics Polymorphism, Genetic Risk Factors |
| title | Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China |
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