Relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in Xinjiang, China

To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in China. The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and rest...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2005-06, Vol.11 (24), p.3651-3654
Hauptverfasser:	Lu, Xiao-Mei, Zhang, Yue-Ming, Lin, Ren-Yong, Arzi, Gul, Wang, Xing, Zhang, Ya-Lou, Zhang, Yan, Wang, Yan, Wen, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged China - epidemiology Cytochrome P-450 CYP2E1 - genetics Esophageal Cancer Esophageal Neoplasms - ethnology Esophageal Neoplasms - genetics Female Genetic Predisposition to Disease - epidemiology Genotype Glutathione Transferase - genetics Humans Kazakhstan - ethnology Male Middle Aged Neoplasms, Squamous Cell - ethnology Neoplasms, Squamous Cell - genetics Polymorphism, Genetic Risk Factors
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Zusammenfassung:	To analyze the relationship between genetic polymorphisms of metabolizing enzymes CYP2E1, GSTM1 and Kazakh's esophageal squamous cell cancer in China. The genotypes of cytochromes P450 (CYP) 2E1 and glutathione S-transferase (GST) M1 were investigated by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) following PCR in 104 Kazakh's patients with esophageal cancer (EC) and 104 non-cancer controls. The frequency of CYP2E1 c1/c1 genotype was significantly higher in patients with cancer (77.9%) than in control subjects (24.0%) (P
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v11.i24.3651