Cholecystokinin octapeptide improves cardiac function by activating cholecystokinin octapeptide receptor in endotoxic shock rats

AIM: To explore the effect of sulfated cholecystokinin octapeptide (sCCK-8) on cardiac functions and its receptor mechanism in endotoxic shock (ES) rats.METHODS: The changes of the mean arterial pressure (MAP), heart rate (HR), the left ventricular pressure (LVP) and the maximal/minimum rate of LVP...

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Veröffentlicht in:World journal of gastroenterology : WJG 2005-06, Vol.11 (22), p.3405-3410
Hauptverfasser: Zhao, Xiao-Yun, Ling, Yi-Ling, Li, Yu-Guang, Meng, Ai-Hong, Xing, Han-Ying
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Sprache:eng
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Zusammenfassung:AIM: To explore the effect of sulfated cholecystokinin octapeptide (sCCK-8) on cardiac functions and its receptor mechanism in endotoxic shock (ES) rats.METHODS: The changes of the mean arterial pressure (MAP), heart rate (HR), the left ventricular pressure (LVP) and the maximal/minimum rate of LVP (±LVdp/dtmax) weremeasured by using physiological record instrument in eight groups of rats. The expression of cholecystoldnin-A receptor (CCK-AR) and cholecystokinin-B receptor (CCK-BR) mRNAof myocardium in ES rats was examined by reverse transcription polymerase chain reaction (RT-PCR).RESULTS: (1) Low doses of sCCK-8 (0.4 llg/kg) caused tachycardia (441+27, normal control 391+22 s/min) and slight increase in MAP, LVP and +LVdp/dtmax (16.96±1.79,18.21±1.69 and +768.85±31.28/-565.04±27.71 kPa,respectively, all P
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i22.3405