First reported case of Ehrlichia ewingii involving human bone marrow

A 65-year-old female with a history of multiple tick bites presented with fever and pancytopenia. Intracytoplasmic rickettsial morulae were detected on peripheral smear and bone marrow biopsy specimens, and PCR amplified Ehrlichia ewingii DNA from both specimens. To our knowledge, this is the first...

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Veröffentlicht in:	Journal of clinical microbiology 2014-11, Vol.52 (11), p.4102-4104
Hauptverfasser:	Allen, M Brandon, Pritt, Bobbi S, Sloan, Lynne M, Paddock, Christopher D, Musham, Chaitanya K, Ramos, Jeanette M, Cetin, Neslihan, Rosenbaum, Eric R
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood - microbiology Bone Marrow - microbiology Bone Marrow - pathology Case Reports DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Ehrlichia - isolation & purification Ehrlichia ewingii Ehrlichiosis - diagnosis Ehrlichiosis - microbiology Ehrlichiosis - pathology Female Granulocytes - microbiology Humans Ixodidae Microscopy Osteomyelitis - diagnosis Osteomyelitis - microbiology Osteomyelitis - pathology Polymerase Chain Reaction Tick Bites - complications
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Zusammenfassung:	A 65-year-old female with a history of multiple tick bites presented with fever and pancytopenia. Intracytoplasmic rickettsial morulae were detected on peripheral smear and bone marrow biopsy specimens, and PCR amplified Ehrlichia ewingii DNA from both specimens. To our knowledge, this is the first report of E. ewingii infection of human bone marrow.
ISSN:	0095-1137 1098-660X
DOI:	10.1128/JCM.01670-14