Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation

Dear Editor, The methylation modifications of histone 3 lysine 4 （H3K4） have essential effects on biological processes including gene expression and transcription, cell cycle progression, and DNA repair. From yeast to mammals, the SET1 and MLL-like （mixed-lineage leukemia） multi-subunit protein complexes, known as SET1 or MLL COMPASS （Schneider et al., 2005）, are responsible for H3K4 methylation. In addition to the catalytic SET domain, the SET1 and MLL COMPASS complexes also contain a number of conserved subunits including WDR5 （Cps30）, RbBP5 （Cps50）.