Reprogramming the genome to totipotency in mouse embryos
Highlights • Totipotent embryos provide insight into efficient genome reprogramming of differentiated cells. • Embryonic genome activation (EGA) correlates with the establishment of totipotency. • Epigenetic remodeling for EGA is central to establishment of totipotency.
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| Veröffentlicht in: | Trends in cell biology 2015-02, Vol.25 (2), p.82-91 |
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| container_title | Trends in cell biology |
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| creator | Zhou, Li-quan Dean, Jurrien |
| description | Highlights • Totipotent embryos provide insight into efficient genome reprogramming of differentiated cells. • Embryonic genome activation (EGA) correlates with the establishment of totipotency. • Epigenetic remodeling for EGA is central to establishment of totipotency. |
| doi_str_mv | 10.1016/j.tcb.2014.09.006 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0962-8924 |
| ispartof | Trends in cell biology, 2015-02, Vol.25 (2), p.82-91 |
| issn | 0962-8924 1879-3088 1879-3088 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Differentiation Cellular Reprogramming - genetics DNA Methylation Embryo, Mammalian - embryology embryonic genome activation Embryonic Stem Cells - cytology Epigenesis, Genetic epigenetic modification Fertilization Genome Germ Cells - cytology Mice Pathology Pluripotent Stem Cells - cytology preimplantation development reprogramming totipotency Totipotent Stem Cells - cytology |
| title | Reprogramming the genome to totipotency in mouse embryos |
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