Reprogramming the genome to totipotency in mouse embryos

Highlights • Totipotent embryos provide insight into efficient genome reprogramming of differentiated cells. • Embryonic genome activation (EGA) correlates with the establishment of totipotency. • Epigenetic remodeling for EGA is central to establishment of totipotency.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in cell biology 2015-02, Vol.25 (2), p.82-91
Hauptverfasser:	Zhou, Li-quan, Dean, Jurrien
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cellular Reprogramming - genetics DNA Methylation Embryo, Mammalian - embryology embryonic genome activation Embryonic Stem Cells - cytology Epigenesis, Genetic epigenetic modification Fertilization Genome Germ Cells - cytology Mice Pathology Pluripotent Stem Cells - cytology preimplantation development reprogramming totipotency Totipotent Stem Cells - cytology
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Beschreibung
Zusammenfassung:	Highlights • Totipotent embryos provide insight into efficient genome reprogramming of differentiated cells. • Embryonic genome activation (EGA) correlates with the establishment of totipotency. • Epigenetic remodeling for EGA is central to establishment of totipotency.
ISSN:	0962-8924 1879-3088 1879-3088
DOI:	10.1016/j.tcb.2014.09.006