Enhancement of leukocyte adhesion after percutaneous irradiation in rats with hepatocellular carcinoma

AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC). METHODS: Twelve ACI rats underwent HCC-inoculation, six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital mic...

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Veröffentlicht in:World journal of gastroenterology : WJG 2005-04, Vol.11 (13), p.1991-1994
Hauptverfasser: Maksan, Sasa-Marcel, Schmidt, Eduard, Ryschich, Eduard, Harms, Wolfgang, Schmidt, Jan
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Sprache:eng
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Zusammenfassung:AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC). METHODS: Twelve ACI rats underwent HCC-inoculation, six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital microscopy was performed. RESULTS: LEI was significantly reduced in tumor tissue. However, irradiation of liver sinusoids and tumor tissue with 6 Gy led to a significant activation of leukocyte adhesion in the tumor with a marked increase of the proinflammatory cytokine TNF-α. CONCLUSION: The findings indicate that the immunological tumor-endothelial barrier can be overcome by external irradiation.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v11.i13.1991