A Fatty Acyl-CoA Oxidizing System in Rat Liver Peroxisomes; Enhancement by Clofibrate, a Hypolipidemic Drug

Purified rat liver peroxisomes contain a cyanide-insensitive fatty acyl-CoA oxidizing system that uses O2and NAD as electron acceptors. The system was detected by the ability of added palmitoyl-CoA to elicit O2consumption, H2O2production, and O2-dependent NAD reduction. The activity of this system i...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1976-06, Vol.73 (6), p.2043-2046
Hauptverfasser:	Lazarow, Paul B., De Duve, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Clofibrate - pharmacology Coenzyme A - metabolism Drug and alcohol surveys Enzymes Glyoxysomes Lipid metabolism Liver Liver - ultrastructure Microbodies - metabolism Mitochondria NAD - metabolism Organoids - metabolism Oxidases Oxidation Oxidation-Reduction Palmitates - metabolism Peroxisomes Rats
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