A Fatty Acyl-CoA Oxidizing System in Rat Liver Peroxisomes; Enhancement by Clofibrate, a Hypolipidemic Drug

A Fatty Acyl-CoA Oxidizing System in Rat Liver Peroxisomes; Enhancement by Clofibrate, a Hypolipidemic Drug

Purified rat liver peroxisomes contain a cyanide-insensitive fatty acyl-CoA oxidizing system that uses O2and NAD as electron acceptors. The system was detected by the ability of added palmitoyl-CoA to elicit O2consumption, H2O2production, and O2-dependent NAD reduction. The activity of this system i...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1976-06, Vol.73 (6), p.2043-2046
Hauptverfasser: Lazarow, Paul B., De Duve, Christian
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Clofibrate - pharmacology
Coenzyme A - metabolism
Drug and alcohol surveys
Enzymes
Glyoxysomes
Lipid metabolism
Liver
Liver - ultrastructure
Microbodies - metabolism
Mitochondria
NAD - metabolism
Organoids - metabolism
Oxidases
Oxidation
Oxidation-Reduction
Palmitates - metabolism
Peroxisomes
Rats
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Beschreibung
Zusammenfassung:Purified rat liver peroxisomes contain a cyanide-insensitive fatty acyl-CoA oxidizing system that uses O2and NAD as electron acceptors. The system was detected by the ability of added palmitoyl-CoA to elicit O2consumption, H2O2production, and O2-dependent NAD reduction. The activity of this system is increased approximately one order of magnitude in rats treated with clofibrate, a hypolipidemic drug known to cause peroxisomal proliferation.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.73.6.2043