Effect of Directly Observed Antiretroviral Therapy Compared to Self-Administered Antiretroviral Therapy on Adherence and Virological Outcomes among HIV-Infected Prisoners: A Randomized Controlled Pilot Study

Effect of Directly Observed Antiretroviral Therapy Compared to Self-Administered Antiretroviral Therapy on Adherence and Virological Outcomes among HIV-Infected Prisoners: A Randomized Controlled Pilot Study

The effect of directly observed therapy (DOT) versus self-administered therapy (SAT) on antiretroviral (ART) adherence and virological outcomes in prison has never been assessed in a randomized, controlled trial. Prisoners were randomized to receive ART by DOT or SAT. The primary outcome was medicat...

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Veröffentlicht in:AIDS and behavior 2015-01, Vol.19 (1), p.128-136
Hauptverfasser: White, Becky L., Golin, Carol E., Grodensky, Catherine A., Kiziah, C. Nichole, Richardson, Amy, Hudgens, Michael G., Wohl, David A., Kaplan, Andrew H.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Anti-HIV Agents - administration & dosage
Antiretroviral agents
Antiretroviral drugs
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Compliance
Directly Observed Therapy
Female
Health Psychology
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
Human immunodeficiency virus
Humans
Infectious Diseases
Male
Medical Research
Medication Adherence - statistics & numerical data
Medications
Medicine
Medicine & Public Health
North Carolina - epidemiology
Original Paper
Participation
Pilot Projects
Prisoners
Prisons
Public Health
Self Administration
Values
Viral Load
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Zusammenfassung:The effect of directly observed therapy (DOT) versus self-administered therapy (SAT) on antiretroviral (ART) adherence and virological outcomes in prison has never been assessed in a randomized, controlled trial. Prisoners were randomized to receive ART by DOT or SAT. The primary outcome was medication adherence [percent of ART doses measured by the medication event monitoring system (MEMS) and pill counts] at the end of 24 weeks. The changes in the plasma viral loads from baseline and proportion of participants virological suppressed (
ISSN:1090-7165
1573-3254
DOI:10.1007/s10461-014-0850-8