AXIN1 and AXIN2 variants in gastrointestinal cancers

Highlights • The AXIN1 and AXIN2 proteins are viewed as tumor suppressors in the Wnt pathway. • We assessed AXIN1/2 sequence variants in gastrointestinal cancers. • AXIN1 may be a tumor suppressor gene in hepatocellular carcinoma. • Germline AXIN2 mutations are linked to a colorectal cancer predispo...

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Veröffentlicht in:	Cancer letters 2014-12, Vol.355 (1), p.1-8
Hauptverfasser:	Mazzoni, Serina M, Fearon, Eric R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Axin Protein - genetics Axin Protein - metabolism Beta-catenin Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Colon cancer Gastric cancer Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - metabolism Gastrointestinal Neoplasms - pathology Genetic Predisposition to Disease Hematology, Oncology and Palliative Medicine Hepatoblastoma - genetics Hepatoblastoma - metabolism Hepatoblastoma - pathology Hepatocellular carcinoma Humans Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Molecular Sequence Data Mutation Phenotype Risk Factors Wnt signaling Wnt Signaling Pathway - genetics
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Zusammenfassung:	Highlights • The AXIN1 and AXIN2 proteins are viewed as tumor suppressors in the Wnt pathway. • We assessed AXIN1/2 sequence variants in gastrointestinal cancers. • AXIN1 may be a tumor suppressor gene in hepatocellular carcinoma. • Germline AXIN2 mutations are linked to a colorectal cancer predisposition syndrome. • The role of AXIN1/2 mutations in other cancers remains to be established.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.09.018