Endothelial nitric oxide synthase uncoupling: A novel pathway in OSA induced vascular endothelial dysfunction

Highlights • OSA patients underwent endothelial reactivity studies and subcutaneous biopsies. • We evaluated endothelial nitric oxide synthase function in patient tissue before and after treatment. • eNOS uncoupling is the cause of endothelial dysfunction and• O2− overproduction in OSA patients. • T...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2015-02, Vol.207, p.40-47
Hauptverfasser:	Varadharaj, Saradhadevi, Porter, Kyle, Pleister, Adam, Wannemacher, Jacob, Sow, Angela, Jarjoura, David, Zweier, Jay L, Khayat, Rami N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biopterins - analogs & derivatives Biopterins - pharmacology Cardiovascular Diseases - etiology Continuous Positive Airway Pressure - methods Endothelial dysfunction Endothelium - drug effects Endothelium - metabolism Enzyme Inhibitors - pharmacology Female Humans Hypertension Male Medical Education Middle Aged NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide Synthase Type III - metabolism Obstructive sleep apnea Pulmonary/Respiratory Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - pathology Sleep Apnea, Obstructive - therapy
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Zusammenfassung:	Highlights • OSA patients underwent endothelial reactivity studies and subcutaneous biopsies. • We evaluated endothelial nitric oxide synthase function in patient tissue before and after treatment. • eNOS uncoupling is the cause of endothelial dysfunction and• O2− overproduction in OSA patients. • Tetrahydrobioterin restored eNOS function in OSA patients’ tissue. • The findings provide a potential pharmacological target to decrease vascular disease in OSA.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2014.12.012