Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers

Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness. A limitation of many scaffolds is that they form surface patches, which are not particularly effective for some types of “wounds” that are deep with...

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Veröffentlicht in:Materials Science & Engineering C 2015-03, Vol.48, p.663-672
Hauptverfasser: Song, Hokyung, Yin, Liya, Chilian, William M., Zhang Newby, Bi-min
Format: Artikel
Sprache:eng
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Zusammenfassung:Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness. A limitation of many scaffolds is that they form surface patches, which are not particularly effective for some types of “wounds” that are deep within tissues, e.g., stroke and myocardial infarction. In this study, we reported the generation of fibrous micro-scaffolds feasible for delivering cells by injection into the tissue parenchyma. The micro-scaffolds (widths
ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2014.12.062