Diversity-Oriented Synthesis of 13- to 18-Membered Macrolactams via Ring-Closing Metathesis

Diversity-Oriented Synthesis of 13- to 18-Membered Macrolactams via Ring-Closing Metathesis

An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying t...

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Veröffentlicht in:Journal of organic chemistry 2011-10, Vol.76 (19), p.8042-8048
Hauptverfasser: Dandapani, Sivaraman, Lowe, Jason T, Comer, Eamon, Marcaurelle, Lisa A
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes - chemistry
Chemistry
Chemistry Techniques, Synthetic - methods
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Lactams, Macrocyclic - chemical synthesis
Lactams, Macrocyclic - chemistry
Organic chemistry
Preparations and properties
Stereoisomerism
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Zusammenfassung:An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo2011957