The role of ventral midline thalamus in cholinergic-based recovery in the amnestic rat

Highlights • Anterior and midline thalamic damage impairs alternation behaviors. • Increasing cholinergic tone across the prefrontal cortex and hippocampus recovers spatial behaviors. • Inactivation of the ventral thalamus blocks the efficacy of cholinergic stimulation.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-01, Vol.285, p.260-268
Hauptverfasser:	Bobal, M.G, Savage, L.M
Format:	Artikel
Sprache:	eng
Schlagworte:	amnesia Animal Feed Animals Cholinesterase Inhibitors - administration & dosage Disease Models, Animal frontal cortex Functional Laterality GABA-A Receptor Agonists - pharmacology hippocampus Hippocampus - drug effects Hippocampus - pathology Hippocampus - physiopathology Korsakoff Syndrome - drug therapy Korsakoff Syndrome - pathology Korsakoff Syndrome - physiopathology Male Maze Learning - drug effects Maze Learning - physiology Muscimol - pharmacology Neurology Physostigmine - administration & dosage Prefrontal Cortex - drug effects Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Pyrithiamine Random Allocation rat Rats, Sprague-Dawley reuniens nucleus memory Thiamine Deficiency - drug therapy Thiamine Deficiency - pathology Thiamine Deficiency - physiopathology Ventral Thalamic Nuclei - drug effects Ventral Thalamic Nuclei - pathology Ventral Thalamic Nuclei - physiopathology
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Beschreibung
Zusammenfassung:	Highlights • Anterior and midline thalamic damage impairs alternation behaviors. • Increasing cholinergic tone across the prefrontal cortex and hippocampus recovers spatial behaviors. • Inactivation of the ventral thalamus blocks the efficacy of cholinergic stimulation.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.11.015