A Randomized Study of Lubiprostone for Opioid‐Induced Constipation in Patients with Chronic Noncancer Pain

A Randomized Study of Lubiprostone for Opioid‐Induced Constipation in Patients with Chronic Noncancer Pain

Objective To evaluate the efficacy and safety of oral lubiprostone for relieving symptoms of opioid‐induced constipation (OIC) in patients with chronic noncancer pain. Design Prospective, randomized, double‐blind, placebo‐controlled trial. Setting Seventy‐nine US and Canadian centers. Subjects Patie...

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Veröffentlicht in:Pain medicine (Malden, Mass.) Mass.), 2014-11, Vol.15 (11), p.1825-1834
Hauptverfasser: Cryer, Byron, Katz, Seymour, Vallejo, Ricardo, Popescu, Anca, Ueno, Ryuji
Format: Artikel
Sprache:eng
Schlagworte:
Alprostadil - analogs & derivatives
Alprostadil - therapeutic use
Analgesics, Opioid - adverse effects
Bowel Movement
Chloride Channel Agonists - therapeutic use
Chronic Pain - drug therapy
ClC‐2
Constipation
Constipation - chemically induced
Constipation - drug therapy
Double-Blind Method
Drug therapy
Female
General Section
Humans
Lubiprostone
Male
Middle Aged
Opioid
Opioid‐Induced Constipation
Pain
Placebo‐Controlled Trial
Prostone
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Zusammenfassung:Objective To evaluate the efficacy and safety of oral lubiprostone for relieving symptoms of opioid‐induced constipation (OIC) in patients with chronic noncancer pain. Design Prospective, randomized, double‐blind, placebo‐controlled trial. Setting Seventy‐nine US and Canadian centers. Subjects Patients aged ≥18 years with OIC, defined as
ISSN:1526-2375
1526-4637
DOI:10.1111/pme.12437