Impact of Body Mass Index on Immunogenicity of Pandemic H1N1 Vaccine in Children and Adults

Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H...

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Veröffentlicht in:	The Journal of infectious diseases 2014-10, Vol.210 (8), p.1270-1274
Hauptverfasser:	Callahan, S. Todd, Wolff, Mark, Hill, Heather R., Edwards, Kathryn M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adolescents Adult Adults Aged Body Mass Index Child Child, Preschool Children Humans Immune response Infant Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - immunology Influenza, Human - prevention & control Influenza, Human - virology Major and Brief Reports Middle Aged Obesity Pandemics Underweight Vaccination VIRUSES Young Adult
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Zusammenfassung:	Obesity emerged as a risk factor for morbidity and mortality related to 2009 pandemic influenza A (H1N1) infection. However, few studies examine the immune responses to H1N1 vaccine among children and adults of various body mass indices (BMI). Pooling data from 3 trials of unadjuvanted split-virus H1N1 A/California/07/2009 influenza vaccines, we analyzed serologic responses of participants stratified by BMI grouping. A single vaccine dose produced higher hemagglutination inhibition antibody titers at day 21 in obese compared to nonobese adults, but there were no significant differences in responses to H1N1 vaccine among children or adults of various BMI following 2 doses.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiu245