Hypothalamic vasopressin systems are more sensitive to the long term effects of social defeat in males versus females

Highlights • We examined effects of social defeat on vasopressin in males and females. • Vasopressin neurons respond similarly during defeat in both sexes. • Defeat reduced vasopressin cell counts and mRNA in only males after several weeks. • Social defeat abolished aggression in females but not mal...

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Veröffentlicht in:	Psychoneuroendocrinology 2015-01, Vol.51, p.122-134
Hauptverfasser:	Steinman, M.Q, Laredo, S.A, Lopez, E.M, Manning, C.E, Hao, R.C, Doig, I.E, Campi, K.L, Flowers, A.E, Knight, J.K, Trainor, B.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggression Animals Arginine Vasopressin - metabolism Conditioned defeat Endocrinology & Metabolism Female Hypothalamus Male Oxytocin Paraventricular Hypothalamic Nucleus - metabolism Peromyscus Psychiatry Septal Nuclei - metabolism Sex Characteristics Sex differences Social Behavior Social defeat Social Dominance Stress Stress, Psychological - metabolism Supraoptic Nucleus - metabolism Vasopressin
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Zusammenfassung:	Highlights • We examined effects of social defeat on vasopressin in males and females. • Vasopressin neurons respond similarly during defeat in both sexes. • Defeat reduced vasopressin cell counts and mRNA in only males after several weeks. • Social defeat abolished aggression in females but not males. • Defeat dissociated vasopressin levels from aggression in males.
ISSN:	0306-4530 1873-3360
DOI:	10.1016/j.psyneuen.2014.09.009