Plasticity of glomeruli and olfactory-mediated behavior in zebrafish following detergent lesioning of the olfactory epithelium

Highlights • Detergent ablation of the olfactory organ disrupts glomeruli in the olfactory bulb. • In general, glomeruli in the medial region of the bulb are the most affected. • By 7 days most glomeruli are morphologically similar to unlesioned controls. • Fish retain the ability to detect amino ac...

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Veröffentlicht in:	Neuroscience 2015-01, Vol.284, p.622-631
Hauptverfasser:	White, E.J, Kounelis, S.K, Byrd-Jacobs, C.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - administration & dosage Animals anti-keyhole limpet hemocyanin Axons - drug effects Axons - physiology Bile Acids and Salts - administration & dosage chemical lesion Danio rerio Detergents - toxicity Female Male Motor Activity - physiology Neurology Neuronal Plasticity - physiology Octoxynol - toxicity Odorants Olfactory Bulb - pathology Olfactory Bulb - physiopathology Olfactory Mucosa - drug effects Olfactory Mucosa - pathology Olfactory Mucosa - physiopathology Olfactory Perception - physiology olfactory sensory neuron Physical Stimulation plasticity Signal Detection, Psychological - physiology teleost Teleostei Time Factors Triton X-100 Zebrafish - physiology
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Zusammenfassung:	Highlights • Detergent ablation of the olfactory organ disrupts glomeruli in the olfactory bulb. • In general, glomeruli in the medial region of the bulb are the most affected. • By 7 days most glomeruli are morphologically similar to unlesioned controls. • Fish retain the ability to detect amino acids after Triton X-100 treatment. • Fish lose detection of bile salts, but they regain olfactory acuity by 10 days.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.10.036