Specific contributions of N-methyl- d -aspartate receptors in the dorsal striatum to cognitive flexibility

Highlights • Reduction of NR1 expression in the dorsal striatum impairs cognitive flexibility. • Partial loss of NR1 expression in the dorsal striatum does not impair motor coordination. • Targeting of NR1 expression in direct pathway causes impaired cognitive flexibility.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2015-01, Vol.284, p.934-942
Hauptverfasser:	Darvas, M, Palmiter, R.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cognition - physiology Corpus Striatum - metabolism direct pathway Dynorphins - metabolism Enkephalins - genetics Enkephalins - metabolism executive function Executive Function - physiology Exploratory Behavior - physiology HEK293 Cells Humans knockout learning Maze Learning - physiology medium spiny neuron Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurology Neuronal Plasticity - physiology plasticity Protein Precursors - genetics Protein Precursors - metabolism Psychomotor Performance - physiology Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Reversal Learning - physiology
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Beschreibung
Zusammenfassung:	Highlights • Reduction of NR1 expression in the dorsal striatum impairs cognitive flexibility. • Partial loss of NR1 expression in the dorsal striatum does not impair motor coordination. • Targeting of NR1 expression in direct pathway causes impaired cognitive flexibility.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.11.011