MicroRNA Expression Profiling in PBMCs: A Potential Diagnostic Biomarker of Chronic Hepatitis C

The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression anal...

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Veröffentlicht in:	Disease markers 2014-01, Vol.2014 (2014), p.1-9
Hauptverfasser:	Tsai, Chia-Hsun, Lai, Hsin-Wu, Hsieh, Wan-Ling, Lin, Chun-Che, Chang, Chiu-Chun, Cheng, Ya-Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological markers Biomarkers - metabolism Blood cells Case-Control Studies Diagnosis Female Gene expression Gene Expression Profiling Genetic aspects Health aspects Hepatitis C Hepatitis C, Chronic - metabolism Humans Identification and classification Leukocytes, Mononuclear - metabolism Male MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Middle Aged
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Zusammenfassung:	The expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 in PBMCs were significantly higher in CHC patients compared with healthy controls and significantly different between CHC patients with HCV genotype 1 (GT-1) and non-genotype-1 (non-GT-1). Multivariate logistic regression analysis also showed that patients with high expression levels of the six target miRNAs had an approximately 7.202-fold risk of CHC compared with those with low expression levels of the target miRNAs. We concluded that the expression levels of miR-16, miR-193b, miR-199a, miR-222, and miR-324 target miRNAs in PBMCs of CHC may act as significant risk biomarkers for the development of CHC.
ISSN:	0278-0240 1875-8630
DOI:	10.1155/2014/367157