Ca2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation

Ca2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation

Calcium (Ca2+) plays a pivotal role in cellular and organismal physiology. The Ca2+ ion has an intermediate protein-binding affinity and thus it can serve as an on/off switch in the regulation of different biochemical processes. The serum level of ionized Ca2+ is regulated with normal ionized Ca2+ b...

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Veröffentlicht in:Biochemical journal 2014-09, Vol.462 (3), p.591-601
Hauptverfasser: Koklic, Tilen, Majumder, Rinku, Lentz, Barry R
Format: Artikel
Sprache:eng
Schlagworte:
Blood Coagulation - physiology
Calcium - metabolism
Factor Xa - metabolism
Humans
Phosphatidylserines - metabolism
Protein Multimerization
Unilamellar Liposomes
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Zusammenfassung:Calcium (Ca2+) plays a pivotal role in cellular and organismal physiology. The Ca2+ ion has an intermediate protein-binding affinity and thus it can serve as an on/off switch in the regulation of different biochemical processes. The serum level of ionized Ca2+ is regulated with normal ionized Ca2+ being in the range 1.10-1.3 mM. Hypocalcaemia (free Ca2+
ISSN:0264-6021
1470-8728
DOI:10.1042/BJ20140130