Epigenetic inheritance: histone bookmarks across generations

Highlights • Histone modifications can persist over multiple cell divisions. • The acquisition of histone marks and full maturation of chromatin continues beyond S-phase. • Polycomb Group (PcG) proteins remain associated with replicated DNA. • Retained histones in sperm may be viable substrates for...

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Veröffentlicht in:	Trends in cell biology 2014-11, Vol.24 (11), p.664-674
Hauptverfasser:	Campos, Eric I, Stafford, James M, Reinberg, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chromatin - genetics DNA Replication Epigenesis, Genetic epigenetic gamete histone Histones - metabolism Humans inheritance Inheritance Patterns Male Pathology polycomb Polycomb-Group Proteins - genetics replication Spermatogenesis
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Histone modifications can persist over multiple cell divisions. • The acquisition of histone marks and full maturation of chromatin continues beyond S-phase. • Polycomb Group (PcG) proteins remain associated with replicated DNA. • Retained histones in sperm may be viable substrates for epigenetic inheritance. • Histones represent a mechanism for the survival of epigenetic information thru generations.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2014.08.004