Methods to study the tumor microenvironment under controlled oxygen conditions

Highlights • Hypoxia, low levels of oxygen concentration, affects cell behavior and fate. • Real-time cell behavior studies in hypoxia are difficult with conventional methods. • Advanced microfluidic platforms allow for precise control over oxygen concentration. • Microfluidic platforms enable real-...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2014-11, Vol.32 (11), p.556-563
Hauptverfasser:	Byrne, Matthew B, Leslie, Matthew T, Gaskins, H. Rex, Kenis, Paul J.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aqueous solutions Behavior Biological and medical sciences Biotechnology Cancer Cell adhesion & migration Cell division Chemicals Cytological Techniques - methods Experimental methods Fundamental and applied biological sciences. Psychology Humans Hypoxia Internal Medicine Laboratories Methods microfluidics Microfluidics - methods Microscopy Mitochondrial DNA Neoplasms - pathology Neoplasms - physiopathology Oxygen Oxygen - metabolism Studies Tumor Microenvironment
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Beschreibung
Zusammenfassung:	Highlights • Hypoxia, low levels of oxygen concentration, affects cell behavior and fate. • Real-time cell behavior studies in hypoxia are difficult with conventional methods. • Advanced microfluidic platforms allow for precise control over oxygen concentration. • Microfluidic platforms enable real-time imaging of cell behavior under hypoxia.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2014.09.006