X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?

•OGT is located on the X-chromosome near XIST.•OGT expression could be sex-biased during early embryogenesis.•In females, OGT may escape X-inactivation altering O-GlcNAcylation and disease development.•Thus, the gender of animals/cells must be considered when conducting O-GlcNAcylation studies. O-Gl...

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Veröffentlicht in:Biochemical and biophysical research communications 2014-10, Vol.453 (2), p.201-207
Hauptverfasser: Olivier-Van Stichelen, Stéphanie, Abramowitz, Lara K., Hanover, John A.
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container_title Biochemical and biophysical research communications
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creator Olivier-Van Stichelen, Stéphanie
Abramowitz, Lara K.
Hanover, John A.
description •OGT is located on the X-chromosome near XIST.•OGT expression could be sex-biased during early embryogenesis.•In females, OGT may escape X-inactivation altering O-GlcNAcylation and disease development.•Thus, the gender of animals/cells must be considered when conducting O-GlcNAcylation studies. O-GlcNAcylation has emerged as a critical post-translational modification important for a wide array of cellular processes. This modification has been identified on a large pool of intracellular proteins that have wide-ranging roles, including transcriptional regulation, cell cycle progression, and signaling, among others. Interestingly, in mammals the single gene encoding O-GlcNAc Transferase (OGT) is located on the X-chromosome near the Xist locus suggesting that tight dosage regulation is necessary for normal development. Herein, we highlight the importance of OGT dosage and consider how its genomic location can contribute to a gender-specific increased risk for a number of diseases.
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subjects Acetylglucosamine - metabolism
Animals
cell cycle
Dosage Compensation, Genetic
Embryogenesis
Embryonic Development - genetics
Embryonic Development - physiology
Female
genes
Genes, X-Linked
Genomic Imprinting
Glycosylation
Humans
loci
Male
mammals
Mice
Models, Biological
N-Acetylglucosaminyltransferases - genetics
N-Acetylglucosaminyltransferases - metabolism
O-GlcNAc Transferase
O-GlcNAcylation
post-translational modification
Pregnancy
Protein Processing, Post-Translational
proteins
risk
transcription (genetics)
X chromosome
X Chromosome Inactivation
X-inactivation
X-linked gene
title X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?
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