X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?
•OGT is located on the X-chromosome near XIST.•OGT expression could be sex-biased during early embryogenesis.•In females, OGT may escape X-inactivation altering O-GlcNAcylation and disease development.•Thus, the gender of animals/cells must be considered when conducting O-GlcNAcylation studies. O-Gl...
Gespeichert in:
Veröffentlicht in: | Biochemical and biophysical research communications 2014-10, Vol.453 (2), p.201-207 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 207 |
---|---|
container_issue | 2 |
container_start_page | 201 |
container_title | Biochemical and biophysical research communications |
container_volume | 453 |
creator | Olivier-Van Stichelen, Stéphanie Abramowitz, Lara K. Hanover, John A. |
description | •OGT is located on the X-chromosome near XIST.•OGT expression could be sex-biased during early embryogenesis.•In females, OGT may escape X-inactivation altering O-GlcNAcylation and disease development.•Thus, the gender of animals/cells must be considered when conducting O-GlcNAcylation studies.
O-GlcNAcylation has emerged as a critical post-translational modification important for a wide array of cellular processes. This modification has been identified on a large pool of intracellular proteins that have wide-ranging roles, including transcriptional regulation, cell cycle progression, and signaling, among others. Interestingly, in mammals the single gene encoding O-GlcNAc Transferase (OGT) is located on the X-chromosome near the Xist locus suggesting that tight dosage regulation is necessary for normal development. Herein, we highlight the importance of OGT dosage and consider how its genomic location can contribute to a gender-specific increased risk for a number of diseases. |
doi_str_mv | 10.1016/j.bbrc.2014.06.068 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4253714</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X14011425</els_id><sourcerecordid>1652390317</sourcerecordid><originalsourceid>FETCH-LOGICAL-c558t-94fe3459231dc685617ad587fa3faf267d09d2db710319d37bcb7cd14b6600a3</originalsourceid><addsrcrecordid>eNqFkcFuFDEMhiMEoqXwAhxQjlxmsTOZzAQhqqpAQarYyx72FmUST5vt7MySZCvx9mS1pYILSJYs2Z9_2f4Ze42wQED1brPo--gWAlAuQJXonrBTBA2VQJBP2SkAqEpoXJ-wFyltABCl0s_ZiZBaAWp1ypZrvrXxLvF8Szzt5vyef5op8ZBLPWeKpWEzX1ZXo_t-4fgq2ikNFG0iHhK3E19XY5juyPMbmuj8JXs22DHRq4d8xlZfPq8uv1bXy6tvlxfXlWuaLldaDlTLRosavVNdo7C1vunawdaDHYRqPWgvfN8i1Kh93faub51H2SsFYOsz9vEou9v3W_KOphztaHYxlGt-mtkG83dnCrfmZr43UjR1i7IIvH0QiPOPPaVstiE5Gkc70bxPBjvRSKwBxf9R1Yhalz3bgooj6uKcUqThcSMEc_DMbMzBM3PwzIAq0ZWhN3_e8jjy26QCfDgCVB56Hyia5AJNjnyI5LLxc_iX_i_C16bA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652390317</pqid></control><display><type>article</type><title>X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Olivier-Van Stichelen, Stéphanie ; Abramowitz, Lara K. ; Hanover, John A.</creator><creatorcontrib>Olivier-Van Stichelen, Stéphanie ; Abramowitz, Lara K. ; Hanover, John A.</creatorcontrib><description>•OGT is located on the X-chromosome near XIST.•OGT expression could be sex-biased during early embryogenesis.•In females, OGT may escape X-inactivation altering O-GlcNAcylation and disease development.•Thus, the gender of animals/cells must be considered when conducting O-GlcNAcylation studies.
O-GlcNAcylation has emerged as a critical post-translational modification important for a wide array of cellular processes. This modification has been identified on a large pool of intracellular proteins that have wide-ranging roles, including transcriptional regulation, cell cycle progression, and signaling, among others. Interestingly, in mammals the single gene encoding O-GlcNAc Transferase (OGT) is located on the X-chromosome near the Xist locus suggesting that tight dosage regulation is necessary for normal development. Herein, we highlight the importance of OGT dosage and consider how its genomic location can contribute to a gender-specific increased risk for a number of diseases.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2014.06.068</identifier><identifier>PMID: 24960196</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acetylglucosamine - metabolism ; Animals ; cell cycle ; Dosage Compensation, Genetic ; Embryogenesis ; Embryonic Development - genetics ; Embryonic Development - physiology ; Female ; genes ; Genes, X-Linked ; Genomic Imprinting ; Glycosylation ; Humans ; loci ; Male ; mammals ; Mice ; Models, Biological ; N-Acetylglucosaminyltransferases - genetics ; N-Acetylglucosaminyltransferases - metabolism ; O-GlcNAc Transferase ; O-GlcNAcylation ; post-translational modification ; Pregnancy ; Protein Processing, Post-Translational ; proteins ; risk ; transcription (genetics) ; X chromosome ; X Chromosome Inactivation ; X-inactivation ; X-linked gene</subject><ispartof>Biochemical and biophysical research communications, 2014-10, Vol.453 (2), p.201-207</ispartof><rights>2014</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c558t-94fe3459231dc685617ad587fa3faf267d09d2db710319d37bcb7cd14b6600a3</citedby><cites>FETCH-LOGICAL-c558t-94fe3459231dc685617ad587fa3faf267d09d2db710319d37bcb7cd14b6600a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X14011425$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24960196$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olivier-Van Stichelen, Stéphanie</creatorcontrib><creatorcontrib>Abramowitz, Lara K.</creatorcontrib><creatorcontrib>Hanover, John A.</creatorcontrib><title>X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>•OGT is located on the X-chromosome near XIST.•OGT expression could be sex-biased during early embryogenesis.•In females, OGT may escape X-inactivation altering O-GlcNAcylation and disease development.•Thus, the gender of animals/cells must be considered when conducting O-GlcNAcylation studies.
O-GlcNAcylation has emerged as a critical post-translational modification important for a wide array of cellular processes. This modification has been identified on a large pool of intracellular proteins that have wide-ranging roles, including transcriptional regulation, cell cycle progression, and signaling, among others. Interestingly, in mammals the single gene encoding O-GlcNAc Transferase (OGT) is located on the X-chromosome near the Xist locus suggesting that tight dosage regulation is necessary for normal development. Herein, we highlight the importance of OGT dosage and consider how its genomic location can contribute to a gender-specific increased risk for a number of diseases.</description><subject>Acetylglucosamine - metabolism</subject><subject>Animals</subject><subject>cell cycle</subject><subject>Dosage Compensation, Genetic</subject><subject>Embryogenesis</subject><subject>Embryonic Development - genetics</subject><subject>Embryonic Development - physiology</subject><subject>Female</subject><subject>genes</subject><subject>Genes, X-Linked</subject><subject>Genomic Imprinting</subject><subject>Glycosylation</subject><subject>Humans</subject><subject>loci</subject><subject>Male</subject><subject>mammals</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>N-Acetylglucosaminyltransferases - genetics</subject><subject>N-Acetylglucosaminyltransferases - metabolism</subject><subject>O-GlcNAc Transferase</subject><subject>O-GlcNAcylation</subject><subject>post-translational modification</subject><subject>Pregnancy</subject><subject>Protein Processing, Post-Translational</subject><subject>proteins</subject><subject>risk</subject><subject>transcription (genetics)</subject><subject>X chromosome</subject><subject>X Chromosome Inactivation</subject><subject>X-inactivation</subject><subject>X-linked gene</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFuFDEMhiMEoqXwAhxQjlxmsTOZzAQhqqpAQarYyx72FmUST5vt7MySZCvx9mS1pYILSJYs2Z9_2f4Ze42wQED1brPo--gWAlAuQJXonrBTBA2VQJBP2SkAqEpoXJ-wFyltABCl0s_ZiZBaAWp1ypZrvrXxLvF8Szzt5vyef5op8ZBLPWeKpWEzX1ZXo_t-4fgq2ikNFG0iHhK3E19XY5juyPMbmuj8JXs22DHRq4d8xlZfPq8uv1bXy6tvlxfXlWuaLldaDlTLRosavVNdo7C1vunawdaDHYRqPWgvfN8i1Kh93faub51H2SsFYOsz9vEou9v3W_KOphztaHYxlGt-mtkG83dnCrfmZr43UjR1i7IIvH0QiPOPPaVstiE5Gkc70bxPBjvRSKwBxf9R1Yhalz3bgooj6uKcUqThcSMEc_DMbMzBM3PwzIAq0ZWhN3_e8jjy26QCfDgCVB56Hyia5AJNjnyI5LLxc_iX_i_C16bA</recordid><startdate>20141017</startdate><enddate>20141017</enddate><creator>Olivier-Van Stichelen, Stéphanie</creator><creator>Abramowitz, Lara K.</creator><creator>Hanover, John A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20141017</creationdate><title>X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?</title><author>Olivier-Van Stichelen, Stéphanie ; Abramowitz, Lara K. ; Hanover, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c558t-94fe3459231dc685617ad587fa3faf267d09d2db710319d37bcb7cd14b6600a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acetylglucosamine - metabolism</topic><topic>Animals</topic><topic>cell cycle</topic><topic>Dosage Compensation, Genetic</topic><topic>Embryogenesis</topic><topic>Embryonic Development - genetics</topic><topic>Embryonic Development - physiology</topic><topic>Female</topic><topic>genes</topic><topic>Genes, X-Linked</topic><topic>Genomic Imprinting</topic><topic>Glycosylation</topic><topic>Humans</topic><topic>loci</topic><topic>Male</topic><topic>mammals</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>N-Acetylglucosaminyltransferases - genetics</topic><topic>N-Acetylglucosaminyltransferases - metabolism</topic><topic>O-GlcNAc Transferase</topic><topic>O-GlcNAcylation</topic><topic>post-translational modification</topic><topic>Pregnancy</topic><topic>Protein Processing, Post-Translational</topic><topic>proteins</topic><topic>risk</topic><topic>transcription (genetics)</topic><topic>X chromosome</topic><topic>X Chromosome Inactivation</topic><topic>X-inactivation</topic><topic>X-linked gene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olivier-Van Stichelen, Stéphanie</creatorcontrib><creatorcontrib>Abramowitz, Lara K.</creatorcontrib><creatorcontrib>Hanover, John A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olivier-Van Stichelen, Stéphanie</au><au>Abramowitz, Lara K.</au><au>Hanover, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene?</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2014-10-17</date><risdate>2014</risdate><volume>453</volume><issue>2</issue><spage>201</spage><epage>207</epage><pages>201-207</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>•OGT is located on the X-chromosome near XIST.•OGT expression could be sex-biased during early embryogenesis.•In females, OGT may escape X-inactivation altering O-GlcNAcylation and disease development.•Thus, the gender of animals/cells must be considered when conducting O-GlcNAcylation studies.
O-GlcNAcylation has emerged as a critical post-translational modification important for a wide array of cellular processes. This modification has been identified on a large pool of intracellular proteins that have wide-ranging roles, including transcriptional regulation, cell cycle progression, and signaling, among others. Interestingly, in mammals the single gene encoding O-GlcNAc Transferase (OGT) is located on the X-chromosome near the Xist locus suggesting that tight dosage regulation is necessary for normal development. Herein, we highlight the importance of OGT dosage and consider how its genomic location can contribute to a gender-specific increased risk for a number of diseases.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24960196</pmid><doi>10.1016/j.bbrc.2014.06.068</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0006-291X |
ispartof | Biochemical and biophysical research communications, 2014-10, Vol.453 (2), p.201-207 |
issn | 0006-291X 1090-2104 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4253714 |
source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Acetylglucosamine - metabolism Animals cell cycle Dosage Compensation, Genetic Embryogenesis Embryonic Development - genetics Embryonic Development - physiology Female genes Genes, X-Linked Genomic Imprinting Glycosylation Humans loci Male mammals Mice Models, Biological N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism O-GlcNAc Transferase O-GlcNAcylation post-translational modification Pregnancy Protein Processing, Post-Translational proteins risk transcription (genetics) X chromosome X Chromosome Inactivation X-inactivation X-linked gene |
title | X marks the spot: Does it matter that O-GlcNAc Transferase is an X-linked gene? |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T09%3A55%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=X%20marks%20the%20spot:%20Does%20it%20matter%20that%20O-GlcNAc%20Transferase%20is%20an%20X-linked%20gene?&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Olivier-Van%20Stichelen,%20St%C3%A9phanie&rft.date=2014-10-17&rft.volume=453&rft.issue=2&rft.spage=201&rft.epage=207&rft.pages=201-207&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1016/j.bbrc.2014.06.068&rft_dat=%3Cproquest_pubme%3E1652390317%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1652390317&rft_id=info:pmid/24960196&rft_els_id=S0006291X14011425&rfr_iscdi=true |