HIV protease inhibitors in gut barrier dysfunction and liver injury
Highlights • The current status of HIV infection and treatment. • HIV protease inhibitors (PIs) induce side effects in GI tract via ER stress. • HIV PIs induce inflammatory response via activation of ER stress. • HIV PIs-induced ER stress and dysfunction of GI contribute to hepatic injury.
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| Veröffentlicht in: | Current opinion in pharmacology 2014-12, Vol.19, p.61-66 |
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| container_end_page | 66 |
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| container_title | Current opinion in pharmacology |
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| creator | Wu, Xudong Li, Yunzhou Peng, Kesong Zhou, Huiping |
| description | Highlights • The current status of HIV infection and treatment. • HIV protease inhibitors (PIs) induce side effects in GI tract via ER stress. • HIV PIs induce inflammatory response via activation of ER stress. • HIV PIs-induced ER stress and dysfunction of GI contribute to hepatic injury. |
| doi_str_mv | 10.1016/j.coph.2014.07.008 |
| format | Article |
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| ispartof | Current opinion in pharmacology, 2014-12, Vol.19, p.61-66 |
| issn | 1471-4892 1471-4973 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antiretroviral Therapy, Highly Active - adverse effects Chemical and Drug Induced Liver Injury - etiology Endoplasmic Reticulum Stress - drug effects Gastrointestinal Diseases - chemically induced Gastrointestinal Tract - drug effects HIV Protease Inhibitors - adverse effects Human immunodeficiency virus Humans Internal Medicine Medical Education |
| title | HIV protease inhibitors in gut barrier dysfunction and liver injury |
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