HIV protease inhibitors in gut barrier dysfunction and liver injury

Highlights • The current status of HIV infection and treatment. • HIV protease inhibitors (PIs) induce side effects in GI tract via ER stress. • HIV PIs induce inflammatory response via activation of ER stress. • HIV PIs-induced ER stress and dysfunction of GI contribute to hepatic injury.

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Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in pharmacology 2014-12, Vol.19, p.61-66
Hauptverfasser:	Wu, Xudong, Li, Yunzhou, Peng, Kesong, Zhou, Huiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiretroviral Therapy, Highly Active - adverse effects Chemical and Drug Induced Liver Injury - etiology Endoplasmic Reticulum Stress - drug effects Gastrointestinal Diseases - chemically induced Gastrointestinal Tract - drug effects HIV Protease Inhibitors - adverse effects Human immunodeficiency virus Humans Internal Medicine Medical Education
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Beschreibung
Zusammenfassung:	Highlights • The current status of HIV infection and treatment. • HIV protease inhibitors (PIs) induce side effects in GI tract via ER stress. • HIV PIs induce inflammatory response via activation of ER stress. • HIV PIs-induced ER stress and dysfunction of GI contribute to hepatic injury.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2014.07.008