Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus

Glycan receptor specificity as a useful tool for characterization and surveillance of influenza A virus

Highlights • Glycan topology beyond terminal linkage clearly demarcates hemagglutinin (HA)–glycan receptor interactions. • Pandemic virus HAs share characteristic biochemical and physiological receptor binding. • Hallmark mutations in naturally evolving avian HAs led to very different receptor bindi...

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Veröffentlicht in:Trends in microbiology (Regular ed.) 2014-11, Vol.22 (11), p.632-641
Hauptverfasser: Raman, Rahul, Tharakaraman, Kannan, Shriver, Zachary, Jayaraman, Akila, Sasisekharan, V, Sasisekharan, Ram
Format: Artikel
Sprache:eng
Schlagworte:
Adaptation, Biological
Animals
Epidemiological Monitoring
glycan
hemagglutinin
Host-Pathogen Interactions
Humans
influenza
Influenza A virus - physiology
Influenza, Human - epidemiology
Influenza, Human - virology
Internal Medicine
network
Orthomyxoviridae Infections - virology
Polysaccharides - metabolism
Receptors, Virus - metabolism
specificity
topology
Virus Attachment
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Beschreibung
Zusammenfassung:Highlights • Glycan topology beyond terminal linkage clearly demarcates hemagglutinin (HA)–glycan receptor interactions. • Pandemic virus HAs share characteristic biochemical and physiological receptor binding. • Hallmark mutations in naturally evolving avian HAs led to very different receptor binding.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2014.07.002