Exposures, mechanisms, and impacts of endocrine-active flame retardants

Highlights • Widespread exposure to flame retardants occurs in indoor environments. • Indoor exposure is associated with body burdens. • Highest human exposures occur in early development, a sensitive window. • PBDEs elicit neurodevelopmental and thyroid hormone disrupting effects. • OPFRs also appe...

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Veröffentlicht in:	Current opinion in pharmacology 2014-12, Vol.19, p.125-133
Hauptverfasser:	Dishaw, Laura V, J Macaulay, Laura, Roberts, Simon C, Stapleton, Heather M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endocrine Disruptors - toxicity Environmental Exposure - adverse effects Environmental Exposure - analysis Flame Retardants - toxicity Halogenated Diphenyl Ethers - toxicity Humans Internal Medicine Medical Education Organophosphates - toxicity Organophosphorus Compounds - toxicity
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Zusammenfassung:	Highlights • Widespread exposure to flame retardants occurs in indoor environments. • Indoor exposure is associated with body burdens. • Highest human exposures occur in early development, a sensitive window. • PBDEs elicit neurodevelopmental and thyroid hormone disrupting effects. • OPFRs also appear to be endocrine active.
ISSN:	1471-4892 1471-4973
DOI:	10.1016/j.coph.2014.09.018