Relationship between expression and distribution of cyclooxygenase-2 and bcl-2 in human gastric adenocarcinoma

AIM: To explore expression and distribution features of COX-2 and bcl-2 in human gastric adenocarcinoma tissues and to study its biological significance. METHODS: Totally 36 human gastric carcinoma samples were enrolled in this study (cardiac adenocarcinoma 16 cases, distal gastric adenocarcinoma 20...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2005-02, Vol.11 (8), p.1228-1231
Hauptverfasser:	Chen, Xiao-Li, Su, Bao-Shan, Sun, Run-Qin, Zhang, Jun, Wang, Yi-Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - secondary bcl-2 Brief Reports Cyclooxygenase 2 Gastric Mucosa - metabolism Gastric Mucosa - pathology Humans Lymphatic Metastasis Membrane Proteins Prostaglandin-Endoperoxide Synthases - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Stomach Neoplasms - metabolism Stomach Neoplasms - pathology 基因分布基因表达环氧合酶-2
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Zusammenfassung:	AIM: To explore expression and distribution features of COX-2 and bcl-2 in human gastric adenocarcinoma tissues and to study its biological significance. METHODS: Totally 36 human gastric carcinoma samples were enrolled in this study (cardiac adenocarcinoma 16 cases, distal gastric adenocarcinoma 20 cases). Theexpressions of COX-2 and bcl-2 in cancerous tissues andcorresponding para-cancerous tissues were investigated by immunohistochemistry using COX-2 polyclonal antibody and bd-2 monodonal antibody. The normal gastric mucosa tissues were used as control. RESULTS: The expressions of COX-2 and bcl-2 in gastric carcinoma were significantly higher than that in the paracancerous tissues (77.8% vs 47.2%, P
ISSN:	1007-9327 2219-2840
DOI:	10.3748/wjg.v11.i8.1228