Toward Intelligent Synthetic Neural Circuits: Directing and Accelerating Neuron Cell Growth by Self-Rolled-Up Silicon Nitride Microtube Array

Toward Intelligent Synthetic Neural Circuits: Directing and Accelerating Neuron Cell Growth by Self-Rolled-Up Silicon Nitride Microtube Array

In neural interface platforms, cultures are often carried out on a flat, open, rigid, and opaque substrate, posing challenges to reflecting the native microenvironment of the brain and precise engagement with neurons. Here we present a neuron cell culturing platform that consists of arrays of ordere...

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Veröffentlicht in:ACS nano 2014-11, Vol.8 (11), p.11108-11117
Hauptverfasser: Froeter, Paul, Huang, Yu, Cangellaris, Olivia V, Huang, Wen, Dent, Erik W, Gillette, Martha U, Williams, Justin C, Li, Xiuling
Format: Artikel
Sprache:eng
Schlagworte:
Arrays
Cell Division
Construction
Culture
Fluorescence
Microscopy, Electron, Scanning
Nanostructure
Neural Networks (Computer)
Neurons
Neurons - cytology
Platforms
Silicon Compounds
Silicon nitride
Three dimensional
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Beschreibung
Zusammenfassung:In neural interface platforms, cultures are often carried out on a flat, open, rigid, and opaque substrate, posing challenges to reflecting the native microenvironment of the brain and precise engagement with neurons. Here we present a neuron cell culturing platform that consists of arrays of ordered microtubes (2.7–4.4 μm in diameter), formed by strain-induced self-rolled-up nanomembrane (s-RUM) technology using ultrathin (
ISSN:1936-0851
1936-086X
DOI:10.1021/nn504876y