Microfluidic continuous-flow radiosynthesis of [ 18 F]FPEB suitable for human PET imaging

The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([ F]FPEB) for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with a commercial continuous-flow microfluidics device. This work represents the first positron emission tomography (PET) r...

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Veröffentlicht in:	MedChemComm 2014-04, Vol.5 (4), p.432-435
Hauptverfasser:	Liang, Steven H, Yokell, Daniel L, Jackson, Raul N, Rice, Peter A, Callahan, Ronald, Johnson, Keith A, Alagille, David, Tamagnan, Gilles, Collier, Thomas Lee, Vasdev, Neil
Format:	Artikel
Sprache:	eng
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Zusammenfassung:	The synthesis of fluorine-18 labeled 3-fluoro-5-[(pyridin-3-yl)ethynyl] benzonitrile ([ F]FPEB) for imaging metabotropic glutamate receptor subtype type 5 (mGluR5) was achieved with a commercial continuous-flow microfluidics device. This work represents the first positron emission tomography (PET) radiopharmaceutical that is suitable for human use with this technology. We also describe a validated synthesis of [ F]FPEB with a commercial reactor-based system.
ISSN:	2040-2503 2040-2511
DOI:	10.1039/c3md00335c