Targeted Delivery of PSC-RANTES for HIV-1 Prevention using Biodegradable Nanoparticles

Purpose Nanoparticles formulated from the biodegradable co-polymer poly(lactic-co-glycolic acid) (PLGA), were investigated as a drug delivery system to enhance tissue uptake, permeation, and targeting for PSC-RANTES anti-HIV-1 activity. Materials and Methods PSC-RANTES nanoparticles formulated via a...

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Veröffentlicht in:	Pharmaceutical research 2009-03, Vol.26 (3), p.502-511
Hauptverfasser:	Ham, Anthony S, Cost, Marilyn R, Sassi, Alexandra B, Dezzutti, Charlene S, Rohan, Lisa Cencia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacokinetics Biochemistry Biocompatible Materials - chemistry Biocompatible Materials - pharmacokinetics Biodegradable materials Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Cervix Uteri - cytology Cervix Uteri - metabolism Chemokine CCL5 - administration & dosage Chemokine CCL5 - pharmacokinetics Chemokine CCL5 - pharmacology Disease prevention Drug Carriers - chemistry Drug Carriers - pharmacokinetics drug delivery Drug delivery systems Female General pharmacology HeLa Cells HIV HIV Fusion Inhibitors - administration & dosage HIV Fusion Inhibitors - pharmacokinetics HIV Fusion Inhibitors - pharmacology HIV Infections - prevention & control HIV Infections - virology HIV-1 - drug effects HIV-1 prevention Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans In Vitro Techniques Infectious diseases Medical Law Medical sciences microbicide Middle Aged Nanoparticles Nanoparticles - chemistry Permeability Pharmaceutical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Prescription drugs PSC-RANTES Research Paper Solubility Surface Properties Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virus Cultivation
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