Genomic landscape of metastatic colorectal cancer

Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumour biology. Here we describe the genomic landscape of tumour samples of a homogeneous well-annotated series of patients with metastatic CRC (mCRC) of two phase III clinical trials, CAIRO and CAIRO2. DNA co...

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Veröffentlicht in:	Nature communications 2014-11, Vol.5 (1), p.5457-5457, Article 5457
Hauptverfasser:	Haan, Josien C., Labots, Mariette, Rausch, Christian, Koopman, Miriam, Tol, Jolien, Mekenkamp, Leonie J. M., van de Wiel, Mark A., Israeli, Danielle, van Essen, Hendrik F., van Grieken, Nicole C. T., Voorham, Quirinus J. M., Bosch, Linda J. W., Qu, Xueping, Kabbarah, Omar, Verheul, Henk M. W., Nagtegaal, Iris D., Punt, Cornelis J. A., Ylstra, Bauke, Meijer, Gerrit A.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1504/1885 631/67/69 Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Atlases as Topic Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - therapeutic use Chromosomes, Human, Pair 6 - genetics Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality DNA Copy Number Variations - genetics Drug Resistance, Neoplasm - genetics Genes, Neoplasm - genetics Genome, Human - genetics Humanities and Social Sciences Humans multidisciplinary Science Science (multidisciplinary) Treatment Outcome
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Zusammenfassung:	Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumour biology. Here we describe the genomic landscape of tumour samples of a homogeneous well-annotated series of patients with metastatic CRC (mCRC) of two phase III clinical trials, CAIRO and CAIRO2. DNA copy number aberrations of 349 patients are determined. Within three treatment arms, 194 chromosomal subregions are associated with progression-free survival (PFS; uncorrected single-test P -values
ISSN:	2041-1723 2041-1723
DOI:	10.1038/ncomms6457