Orexin/Hypocretin Activates mTOR Complex 1 (mTORC1) via an Erk/Akt-independent and Calcium-stimulated Lysosome v-ATPase Pathway

The lack of the neuropeptide orexin, also known as hypocretin, results in narcolepsy, a chronic sleep disorder characterized by frequent sleep/cataplexy attacks and rapid eye movement sleep abnormalities. However, the downstream pathways of orexin signaling are not clearly understood. Here, we show...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2014-11, Vol.289 (46), p.31950-31959
Hauptverfasser:	Wang, Zhiqiang, Liu, Shimeng, Kakizaki, Miyo, Hirose, Yuuki, Ishikawa, Yukiko, Funato, Hiromasa, Yanagisawa, Masashi, Yu, Yonghao, Liu, Qinghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Calcium - metabolism Cell Line Cytoplasm - metabolism Enzyme Activation Extracellular Signal-Regulated MAP Kinases - metabolism Gene Expression Regulation, Enzymologic HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - metabolism Lysosomes - metabolism Mechanistic Target of Rapamycin Complex 1 Mice Mice, Inbred C57BL Mice, Transgenic Multiprotein Complexes - metabolism Neuropeptides - metabolism Orexin Receptors - metabolism Orexins Proto-Oncogene Proteins c-akt - metabolism RNA Interference Signal Transduction TOR Serine-Threonine Kinases - metabolism Vacuolar Proton-Translocating ATPases - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!