$Thermoase-derived flaxseed protein hydrolysates and membrane ultrafiltration peptide fractions have systolic blood pressure-lowering effects in spontaneously hypertensive rats$

Thermoase-derived flaxseed protein hydrolysates and membrane ultrafiltration peptide fractions have systolic blood pressure-lowering effects in spontaneously hypertensive rats

Thermoase-digested flaxseed protein hydrolysate (FPH) samples and ultrafiltration membrane-separated peptide fractions were initially evaluated for in vitro inhibition of angiotensin I-converting enzyme (ACE) and renin activities. The two most active FPH samples and their corresponding peptide fract...

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Veröffentlicht in:	International journal of molecular sciences 2014-10, Vol.15 (10), p.18131-18147
Hauptverfasser:	Nwachukwu, Ifeanyi D, Girgih, Abraham T, Malomo, Sunday A, Onuh, John O, Aluko, Rotimi E
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors - chemistry Angiotensin-Converting Enzyme Inhibitors - isolation & purification Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals Antihypertensive Agents - chemistry Antihypertensive Agents - isolation & purification Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Flax Flax - chemistry Humans Hypertension Hypertension - drug therapy Hypertension - physiopathology Male Peptides Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - therapeutic use Plant Proteins - chemistry Plant Proteins - isolation & purification Plant Proteins - therapeutic use Proteins Rats, Inbred SHR Renin - antagonists & inhibitors Rodents Seeds - chemistry Ultrafiltration
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Zusammenfassung:	Thermoase-digested flaxseed protein hydrolysate (FPH) samples and ultrafiltration membrane-separated peptide fractions were initially evaluated for in vitro inhibition of angiotensin I-converting enzyme (ACE) and renin activities. The two most active FPH samples and their corresponding peptide fractions were subsequently tested for in vivo antihypertensive activity in spontaneously hypertensive rats (SHR). The FPH produced with 3% thermoase digestion showed the highest ACE- and renin-inhibitory activities. Whereas membrane ultrafiltration resulted in significant (p < 0.05) increases in ACE inhibition by the
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms151018131