White matter hyperintensities and hypobaric exposure

White matter hyperintensities and hypobaric exposure

Objective Demonstrate that occupational exposure to nonhypoxic hypobaria is associated with subcortical white matter hyperintensities (WMHs) on fluid‐attenuated inversion recovery magnetic resonance imaging (MRI). Methods Eighty‐three altitude chamber personnel (PHY), 105 U‐2 pilots (U2P), and 148 a...

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Veröffentlicht in:Annals of neurology 2014-11, Vol.76 (5), p.719-726
Hauptverfasser: McGuire, Stephen A., Sherman, Paul M., Wijtenburg, S. Andrea, Rowland, Laura M., Grogan, Patrick M., Sladky, John H., Robinson, Andrew Y., Kochunov, Peter V.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aging
Air Pressure
Altitude
Atmosphere Exposure Chambers
Female
Follow-Up Studies
Health risk assessment
Humans
Hypoxia, Brain - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Military Personnel
Occupational Exposure
White Matter - pathology
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Zusammenfassung:Objective Demonstrate that occupational exposure to nonhypoxic hypobaria is associated with subcortical white matter hyperintensities (WMHs) on fluid‐attenuated inversion recovery magnetic resonance imaging (MRI). Methods Eighty‐three altitude chamber personnel (PHY), 105 U‐2 pilots (U2P), and 148 age‐ controlled and health‐matched doctorate degree controls (DOC) underwent high‐resolution MRI. Subcortical WMH burden was quantified as count and volume of subcortical WMH lesions after transformation of images to the Talairach atlas–based stereotactic frame. Results Subcortical WMHs were more prevalent in PHY (volume p = 0.011/count p = 0.019) and U2P (volume p 
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.24264