Programmed death-1 expression on CD4+ and CD8+ T cells in treated and untreated HIV disease

BACKGROUND:There is intense interest in the role of programmed death 1 (PD-1) in causing persistent T-cell dysfunction in HIV infection. However, the impact of HIV infection and antiretroviral treatment (ART) on the expression of PD-1 on T cells is still poorly defined. METHODS:PD-1 was measured lon...

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Veröffentlicht in:	AIDS (London) 2014-07, Vol.28 (12), p.1749-1758
Hauptverfasser:	Cockerham, Leslie R, Jain, Vivek, Sinclair, Elizabeth, Glidden, David V, Hartogenesis, Wendy, Hatano, Hiroyu, Hunt, Peter W, Martin, Jeffrey N, Pilcher, Christopher D, Sekaly, Rafick, McCune, Joseph M, Hecht, Frederick M, Deeks, Steven G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AIDS/HIV Anti-Retroviral Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD4-Positive T-Lymphocytes - chemistry CD8-Positive T-Lymphocytes - chemistry CD8-Positive T-Lymphocytes - immunology Cohort Studies Female HIV Infections - drug therapy HIV Infections - pathology Human viral diseases Humans Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infectious diseases Longitudinal Studies Lymphocyte Activation Male Medical sciences Middle Aged Pharmacology. Drug treatments Programmed Cell Death 1 Receptor - analysis Prospective Studies RNA, Viral - blood Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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Zusammenfassung:	BACKGROUND:There is intense interest in the role of programmed death 1 (PD-1) in causing persistent T-cell dysfunction in HIV infection. However, the impact of HIV infection and antiretroviral treatment (ART) on the expression of PD-1 on T cells is still poorly defined. METHODS:PD-1 was measured longitudinally in a cohort of recently HIV-infected individuals (n = 121) who started ART early (
ISSN:	0269-9370 1473-5571
DOI:	10.1097/QAD.0000000000000314