Relationship between metabolic enzyme polymorphism and colorectal cancer
AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. ManteI-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied i...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2005-01, Vol.11 (3), p.331-335 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Chen, Kun Jiang, Qin-Ting He, Han-Qing |
| description | AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. ManteI-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P0.05).CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTF1 deletion,NAT2-rapid acetylator phenotype and genotye and NAT2rapid acetylator phenotype. |
| doi_str_mv | 10.3748/wjg.v11.i3.331 |
| format | Article |
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ManteI-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYPIA1 L1e462Val, CYPIA1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05).CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTF1 deletion,NAT2-rapid acetylator phenotype and genotye and NAT2rapid acetylator phenotype.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v11.i3.331</identifier><identifier>PMID: 15637738</identifier><language>eng</language><publisher>United States: Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China</publisher><subject>Arylamine N-Acetyltransferase - genetics ; Colorectal Cancer ; Colorectal Neoplasms - genetics ; Gene Deletion ; Genetic Predisposition to Disease ; Genotype ; Glutathione Transferase - genetics ; Humans ; N-乙酰基转移酶 ; Phenotype ; Polymorphism, Genetic ; 代谢酶 ; 基因多肽性 ; 消化系统 ; 结直肠癌 ; 谷胱甘肽S-转移酶</subject><ispartof>World journal of gastroenterology : WJG, 2005-01, Vol.11 (3), p.331-335</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2005 Baishideng Publishing Group Co., Limited. All rights reserved. 2005</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-a181774014b8ecd4b5291b2652c7852ee7570bccb13026a950b66beb7c2985f33</citedby><cites>FETCH-LOGICAL-c444t-a181774014b8ecd4b5291b2652c7852ee7570bccb13026a950b66beb7c2985f33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205331/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205331/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15637738$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Kun</creatorcontrib><creatorcontrib>Jiang, Qin-Ting</creatorcontrib><creatorcontrib>He, Han-Qing</creatorcontrib><title>Relationship between metabolic enzyme polymorphism and colorectal cancer</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. ManteI-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYPIA1 L1e462Val, CYPIA1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05).CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTF1 deletion,NAT2-rapid acetylator phenotype and genotye and NAT2rapid acetylator phenotype.</description><subject>Arylamine N-Acetyltransferase - genetics</subject><subject>Colorectal Cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Gene Deletion</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>N-乙酰基转移酶</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic</subject><subject>代谢酶</subject><subject>基因多肽性</subject><subject>消化系统</subject><subject>结直肠癌</subject><subject>谷胱甘肽S-转移酶</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1rFDEchoModlu9epRBpLcZ852ZiyBFrVAQRM8hyf5mN2smmSazXda_3pRd_DjlkIcnb94XoVcEd0zx_t1ht-keCOk86xgjT9CKUjK0tOf4KVoRjFU7MKou0GUpO4wpY4I-RxdESKYU61fo9hsEs_gUy9bPjYXlABCbCRZjU_CugfjrOEEzp3CcUp63vkyNievGpZAyuMWExpnoIL9Az0YTCrw8n1fox6eP329u27uvn7_cfLhrHed8aQ3piVIcE257cGtuBR2IpVJQp3pBAZRQ2DpnCcNUmkFgK6UFqxwdejEydoXen7zz3k6wdhCXbIKes59MPupkvP7_Jvqt3qQHzSkWtaIqeHsSHEwcTdzoXdrnWCPr2iXFWGCGsazY9fmdnO73UBY9-eIgBBMh7YuWiomBS1HB7gS6nErJMP7JQrB-3OjRq-tG2jN9CvD63x_8xc-jVODN2bhNcXPva0Zr3M_RB9CESCVqh-w3auyabg</recordid><startdate>20050121</startdate><enddate>20050121</enddate><creator>Chen, Kun</creator><creator>Jiang, Qin-Ting</creator><creator>He, Han-Qing</creator><general>Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China</general><general>Baishideng Publishing Group Co., Limited</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20050121</creationdate><title>Relationship between metabolic enzyme polymorphism and colorectal cancer</title><author>Chen, Kun ; Jiang, Qin-Ting ; He, Han-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-a181774014b8ecd4b5291b2652c7852ee7570bccb13026a950b66beb7c2985f33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Arylamine N-Acetyltransferase - genetics</topic><topic>Colorectal Cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Gene Deletion</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>N-乙酰基转移酶</topic><topic>Phenotype</topic><topic>Polymorphism, Genetic</topic><topic>代谢酶</topic><topic>基因多肽性</topic><topic>消化系统</topic><topic>结直肠癌</topic><topic>谷胱甘肽S-转移酶</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Kun</creatorcontrib><creatorcontrib>Jiang, Qin-Ting</creatorcontrib><creatorcontrib>He, Han-Qing</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Kun</au><au>Jiang, Qin-Ting</au><au>He, Han-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between metabolic enzyme polymorphism and colorectal cancer</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2005-01-21</date><risdate>2005</risdate><volume>11</volume><issue>3</issue><spage>331</spage><epage>335</epage><pages>331-335</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. ManteI-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P<0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYPIA1 L1e462Val, CYPIA1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P>0.05).CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTF1 deletion,NAT2-rapid acetylator phenotype and genotye and NAT2rapid acetylator phenotype.</abstract><cop>United States</cop><pub>Department of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China</pub><pmid>15637738</pmid><doi>10.3748/wjg.v11.i3.331</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of gastroenterology : WJG, 2005-01, Vol.11 (3), p.331-335 |
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| subjects | Arylamine N-Acetyltransferase - genetics Colorectal Cancer Colorectal Neoplasms - genetics Gene Deletion Genetic Predisposition to Disease Genotype Glutathione Transferase - genetics Humans N-乙酰基转移酶 Phenotype Polymorphism, Genetic 代谢酶 基因多肽性 消化系统 结直肠癌 谷胱甘肽S-转移酶 |
| title | Relationship between metabolic enzyme polymorphism and colorectal cancer |
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