Relationship between metabolic enzyme polymorphism and colorectal cancer

AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. ManteI-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)rapid acetylator phenotype and genotye (pooled OR = 1.08) and NAT2-rapid acetylator phenotype (pooled OR = 1.15) had a significantly increased risk for colorectal cancer (P0.05).CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTF1 deletion,NAT2-rapid acetylator phenotype and genotye and NAT2rapid acetylator phenotype.