Serum annexin A2 levels in patients with colon cancer in comparison to healthy controls and in relation to tumor pathology

The deregulation and localization of the Annexins is consistently reported to have close relation to tumor cell malignancy, invasion, and metastasis as well as clinical progression of tumors. This study aimed to evaluate serum Annexin A2 (Anx A2) levels in patients with colon cancer in comparison to...

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Veröffentlicht in:Medical science monitor 2014-10, Vol.20, p.1801-1807
Hauptverfasser: Gurluler, Ercument, Guner, Osman Serhat, Tumay, Latif Volkan, Turkel Kucukmetin, Nurten, Hizli, Banu, Zorluoglu, Abdullah
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Sprache:eng
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Zusammenfassung:The deregulation and localization of the Annexins is consistently reported to have close relation to tumor cell malignancy, invasion, and metastasis as well as clinical progression of tumors. This study aimed to evaluate serum Annexin A2 (Anx A2) levels in patients with colon cancer in comparison to healthy controls and in relation to demographics and tumor pathology. A total of 100 patients (mean (SD) age: 58 (5.8) years, 55.0% females) with colon cancer and 70 controls (mean (SD) age: 59 (5.4) years, 50.0% females) were included. Serum levels for Anx A2 were evaluated in relation to study group, demographics, and tumor pathology. Serum levels for Anx A2 were significantly lower in patients with colon cancer than in controls (13.1 (4.5) vs. 22.8 (2.1) ng/mL, p
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/MSM.892319