Early exposure to bisphenol A alters neuron and glia number in the rat prefrontal cortex of adult males, but not females

Highlights • Pregnant females received 0, 4, 40, or 400-μg/kg/day BPA throughout gestation. • Male and female offspring were orally given the same dose from postnatal days 1 to 9. • In adulthood, neuron and glia numbers in the medial prefrontal cortex were quantified using stereological techniques....

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Veröffentlicht in:	Neuroscience 2014-10, Vol.279, p.122-131
Hauptverfasser:	Sadowski, R.N, Wise, L.M, Park, P.Y, Schantz, S.L, Juraska, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autism Benzhydryl Compounds - toxicity BPA Cell Count Dose-Response Relationship, Drug Estrogens, Non-Steroidal - toxicity Female glia number Gray Matter - drug effects Gray Matter - growth & development Gray Matter - pathology Gray Matter - physiopathology Image Processing, Computer-Assisted Male Neuroglia - drug effects Neuroglia - pathology Neuroglia - physiology Neurology neuron number Neurons - drug effects Neurons - pathology Neurons - physiology Organ Size Phenols - toxicity prefrontal cortex Prefrontal Cortex - drug effects Prefrontal Cortex - growth & development Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Pregnancy Prenatal Exposure Delayed Effects Rats, Long-Evans Sex Characteristics White Matter - drug effects White Matter - growth & development White Matter - pathology White Matter - physiopathology
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Zusammenfassung:	Highlights • Pregnant females received 0, 4, 40, or 400-μg/kg/day BPA throughout gestation. • Male and female offspring were orally given the same dose from postnatal days 1 to 9. • In adulthood, neuron and glia numbers in the medial prefrontal cortex were quantified using stereological techniques. • Males exposed to 400-μg/kg/day BPA during development had more neurons and glia in layers 5/6 compared to male controls. • Females were unaffected.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2014.08.038