The mechanistic basis of arsenicosis: Pathogenesis of skin cancer
Highlights • About 200 million people worldwide are at risk of toxic arsenic exposure. • Skin lesions indicate progression of other diseases. • Mitochondria-dependent oxidative and nitrosative stress contribute to pathogenesis. • Immune dysfunctions are mediated by unfolded protein response signalin...
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Veröffentlicht in: | Cancer letters 2014-11, Vol.354 (2), p.211-219 |
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creator | Hunt, Katherine M Srivastava, Ritesh K Elmets, Craig A Athar, Mohammad |
description | Highlights • About 200 million people worldwide are at risk of toxic arsenic exposure. • Skin lesions indicate progression of other diseases. • Mitochondria-dependent oxidative and nitrosative stress contribute to pathogenesis. • Immune dysfunctions are mediated by unfolded protein response signaling. • Arsenic alters genomic stability and disrupts various signal transduction pathways. |
doi_str_mv | 10.1016/j.canlet.2014.08.016 |
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source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
subjects | Animals Arsenic Arsenic Poisoning - pathology Arsenicosis Carcinogenesis Drinking water Environmental Exposure - adverse effects Groundwater - analysis Hematology, Oncology and Palliative Medicine Humans Metabolites Mortality Oxidative stress Pathogenesis Proto-Oncogene Mas Skin Neoplasms - chemically induced |
title | The mechanistic basis of arsenicosis: Pathogenesis of skin cancer |
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