The mechanistic basis of arsenicosis: Pathogenesis of skin cancer

Highlights • About 200 million people worldwide are at risk of toxic arsenic exposure. • Skin lesions indicate progression of other diseases. • Mitochondria-dependent oxidative and nitrosative stress contribute to pathogenesis. • Immune dysfunctions are mediated by unfolded protein response signalin...

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Veröffentlicht in:	Cancer letters 2014-11, Vol.354 (2), p.211-219
Hauptverfasser:	Hunt, Katherine M, Srivastava, Ritesh K, Elmets, Craig A, Athar, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenic Arsenic Poisoning - pathology Arsenicosis Carcinogenesis Drinking water Environmental Exposure - adverse effects Groundwater - analysis Hematology, Oncology and Palliative Medicine Humans Metabolites Mortality Oxidative stress Pathogenesis Proto-Oncogene Mas Skin Neoplasms - chemically induced
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Zusammenfassung:	Highlights • About 200 million people worldwide are at risk of toxic arsenic exposure. • Skin lesions indicate progression of other diseases. • Mitochondria-dependent oxidative and nitrosative stress contribute to pathogenesis. • Immune dysfunctions are mediated by unfolded protein response signaling. • Arsenic alters genomic stability and disrupts various signal transduction pathways.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.08.016