A new HCV mouse model on the block

The investigation of virus-induced liver disease and hepatocellular carcinoma needs small animal models modeling hepatitis C virus （HCV） infection and liver disease biology. A recent study published in Cell Research reports a novel mouse model which is permissive for chronic HCV infection and shows...

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Veröffentlicht in:	Cell research 2014-10, Vol.24 (10), p.1153-1154
Hauptverfasser:	Tawar, Rajiv G, Mailly, Laurent, Baumert, Thomas F
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/767/1424 692/699/1503/1607 692/699/1503/1607/234/2513/1551 Animal models Animals Biomedical and Life Sciences Cell Biology Female HCV Hepacivirus - physiology Hepatitis Hepatitis C - immunology Hepatitis C - virology Human health and pathology Humans Immunocompetence Life Sciences Liver Liver - pathology Liver - virology Male Research Highlight 丙型肝炎病毒动物模型小鼠模型病毒性病毒感染纤维化肝损伤
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Beschreibung
Zusammenfassung:	The investigation of virus-induced liver disease and hepatocellular carcinoma needs small animal models modeling hepatitis C virus （HCV） infection and liver disease biology. A recent study published in Cell Research reports a novel mouse model which is permissive for chronic HCV infection and shows chronic liver injury including inflammation, steatosis and fibrosis.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2014.126